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The effects of alendronate treatment in the diagnosis and management of proximal femur osteoporosis: A real-life scenario

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dc.contributor.author Asadullah, Muhammad
dc.contributor.author Sarfaraz, Sana
dc.contributor.author Tanzil, Sana
dc.contributor.author Ikram, Rahela
dc.contributor.author Kamil, Noor
dc.date.accessioned 2022-10-19T05:29:38Z
dc.date.available 2022-10-19T05:29:38Z
dc.date.issued 2021-07-20
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13253
dc.description.abstract Currently the increased focus is being given to reforming osteoporosis regimens. Optimizing the evaluation of pharmacological intervention occurs once a medicine has been approved. There is literature available on the use of alendronate in bone loss. The current study focuses on the efficacy assessment of alendronate on proximal femur bone density loss. Current work was carried out to analyze the data of the BMD. The study comprised of females who had received at least six months of Alendronate (70mg/week) for proximal femur osteoporosis. SPSS version-22 was used for analysis and a comparative change was regarded therapeutically significant. The reliability of the research was ensured by reporting cover-up and withdrawals. Among all the study participants who received Alendronate therapy the median height of females in centimeters (cms) was 155 (IQR =16) and the median weight was 55.5 Kilograms (Kgs) (IQR =15). The mean age of the population was 50.59±14.714. The study found the median T-score before therapy was -2.9 (IQR=0.7) and the median T-score after therapy was -2.51(IQR=1). The estimated difference of mean rank was statistically significant for pre- and post-therapy T-score (p=0.008). Hence, the results of this study indicate an improvement in BMD as a result of therapy. Alendronate at 70 mg per week is effective in reducing hip osteoporosis en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Alendronate en_US
dc.subject bone mineral density en_US
dc.subject hip fractures en_US
dc.subject osteoporosis en_US
dc.title The effects of alendronate treatment in the diagnosis and management of proximal femur osteoporosis: A real-life scenario en_US
dc.type Article en_US


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