Abstract:
α- β unsaturated carboxylic acids containing a heterocyclic moiety is one of the most potent class of bioactive
compounds whose speedy generation through novel synthetic techniques has become an enigma for the synthetic
chemists. This research project demonstrates a novel method for the synthesis of these compounds using polymersupported microwave-assisted methodology carried out through one-pot multicomponent reaction. Both soluble and
insoluble polymers have been used and their results are comprehensively analyzed. Moreover, the compounds are
characterized through spectral analysis like FTIR, GC-MASS, 1HNMR Spectroscopy. The cytotoxicity of synthesized
compounds is evaluated through MTT assay using HEPG 2 cells.
