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Synthesis and cytotoxicity evaluation of alpha beta unsaturated carboxylic acids of thiophene analogs by using polymer supported microwave-assisted method

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dc.contributor.author Hassan, Jhanara
dc.contributor.author Ehsan, Shahana
dc.contributor.author Shahnaz
dc.contributor.author Khan, Tahira Moen
dc.contributor.author Saghir, Tahira
dc.date.accessioned 2022-10-19T05:31:38Z
dc.date.available 2022-10-19T05:31:38Z
dc.date.issued 2021-07-20
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13257
dc.description.abstract α- β unsaturated carboxylic acids containing a heterocyclic moiety is one of the most potent class of bioactive compounds whose speedy generation through novel synthetic techniques has become an enigma for the synthetic chemists. This research project demonstrates a novel method for the synthesis of these compounds using polymersupported microwave-assisted methodology carried out through one-pot multicomponent reaction. Both soluble and insoluble polymers have been used and their results are comprehensively analyzed. Moreover, the compounds are characterized through spectral analysis like FTIR, GC-MASS, 1HNMR Spectroscopy. The cytotoxicity of synthesized compounds is evaluated through MTT assay using HEPG 2 cells. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject αβ unsaturated carboxylic acids en_US
dc.subject polymer-supported en_US
dc.subject microwave-assisted en_US
dc.subject solvent free en_US
dc.subject one-pot en_US
dc.subject multicomponent en_US
dc.subject anti-cancer activity en_US
dc.title Synthesis and cytotoxicity evaluation of alpha beta unsaturated carboxylic acids of thiophene analogs by using polymer supported microwave-assisted method en_US
dc.type Article en_US


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