PASTIC Dspace Repository

Effect of vasopressin on electrocardiographic changes produced by ischemia-reperfusion in rats

Show simple item record

dc.contributor.author Nazari, Afshin
dc.contributor.author Mohamadi, Asghar
dc.contributor.author Imani, Ali Reza
dc.contributor.author Faghihi, Mahdieh
dc.contributor.author Tarahi, Mohamad Javad
dc.contributor.author Moghimian, Maryam
dc.contributor.author Cheraghi, Mostafa
dc.date.accessioned 2022-10-19T05:33:08Z
dc.date.available 2022-10-19T05:33:08Z
dc.date.issued 2021-07-20
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13258
dc.description.abstract The present study was conducted to identify the effect of vasopressin (AVP) on electrocardiographic changes produced by ischemia-reperfusion . Male rats were divided into seven groups (n=8-13) subjected to 30min ischemia and 120 min reperfusion. In protocol I (control group), saline was administered before ischemia. In protocol II, different doses of AVP (0.015, 0.03, 0.06 and 0.12μg/rat) were infused 10 min before ischemia. In protocol III SR49059 (1 mg/kg), was injected 20 min prior to ischemia with and without the effective dose of AVP (0.03 g/rat). Ischemia-induced arrhythmia and myocardial infarct size (IS) were measured. Different doses of vasopressin decreased IS. There were no significant differences in PR, QRS duration and ΔT/ΔST ratio between control and intervention groups in ischemia. ST elevation was significantly increased in control and AVP 0.015, 0.03, 0.06 groups during ischemia. In AVP 0.12 group there was no significant difference in ST deviation between the baseline and ischemia phase. JT interval was significantly increased in control and antagonist group during ischemia. AVP 0.12μg/rat prevented the increase of JT interval in ischemia compared to the baseline. In summary, AVP mediated preconditioning improved ST resolution, prevented prolongation of JT interval and decreased the likelihood of subsequently ventricular arrhythmia. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Vasopressin en_US
dc.subject ischemia-reperfusion injury en_US
dc.subject electrocardiogram parameters en_US
dc.title Effect of vasopressin on electrocardiographic changes produced by ischemia-reperfusion in rats en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account