Abstract:
Seven new hydrazinyl thiazole derivatives of piperidin-4-one (PE3-PE9) have been synthesized by cyclization
of intermediate thiosemicarbazone derivative (PE2). Parent molecule (PE1) was synthesized by one pot total synthesis
using Mannich condensation reaction. Percent yield of most of the compounds found in between 70-85%. Compounds
were identified by spectroscopic analysis. In vivo analgesic activity was examined using tail flick method. one-way
ANOVA was used to compare the mean latency time of synthesized derivatives with control and standard. Analgesic
activity was discussed in terms of structural differences between compounds. Among all the derivatives
thiosemicarbazone derivative showed good analgesic activity (195.24%). Methoxy (-OCH3) and bromo (-Br) containing
thiazole derivative also showed good pain reducing property (167.62%, 203%) at a dose of 30mg/kg.
