Abstract:
In the management of cardiovascular disorders, medicines from herbal sources have played a vital role
through centuries. The following study was commenced in order to lay possible pharmacological foundation associated
with medicinal uses of edible fruit of Grewia asiatica in hypertension through in-vitro method. In this study isolated
atrial preparation of Guinea pig was used where crude ethanolic extract of Grewia asiatica fruit (Ga.Cr) decreased the
force and rate of spontaneous atrial contractions (0.03-10mg/kg). In isolated rat aortic ring preparations previously
vasoconstricted by phenylephrine and High K+
, it also resulted in dose dependent vasodilation (0.01-10 mg/kg).In the
presence of L-NAME, the relaxation curve of Ga.Cr was partially inhibited showing involvement of Nitric oxide (NO)
mediated pathway. The speculative analysis contemplated that Ga.Cr has blood pressure reducing potentials through
inhibition of Ca++ influx via Ca++ channels, its release from intracellular stores and through other means like NO
mediated pathways.
