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Pharmacological basis for the antihypertensive activity of Grewia asiatica fruit extract

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dc.contributor.author akram, zuneera
dc.contributor.author Perveen, Rehana
dc.contributor.author Siddiqi, Hasan Salman
dc.contributor.author Hussain, Muzammil
dc.contributor.author Imam, Shahlla
dc.contributor.author Abrar, Hina
dc.contributor.author Mahmood, Syed Mohammad
dc.date.accessioned 2022-10-19T05:34:37Z
dc.date.available 2022-10-19T05:34:37Z
dc.date.issued 2021-07-20
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13261
dc.description.abstract In the management of cardiovascular disorders, medicines from herbal sources have played a vital role through centuries. The following study was commenced in order to lay possible pharmacological foundation associated with medicinal uses of edible fruit of Grewia asiatica in hypertension through in-vitro method. In this study isolated atrial preparation of Guinea pig was used where crude ethanolic extract of Grewia asiatica fruit (Ga.Cr) decreased the force and rate of spontaneous atrial contractions (0.03-10mg/kg). In isolated rat aortic ring preparations previously vasoconstricted by phenylephrine and High K+ , it also resulted in dose dependent vasodilation (0.01-10 mg/kg).In the presence of L-NAME, the relaxation curve of Ga.Cr was partially inhibited showing involvement of Nitric oxide (NO) mediated pathway. The speculative analysis contemplated that Ga.Cr has blood pressure reducing potentials through inhibition of Ca++ influx via Ca++ channels, its release from intracellular stores and through other means like NO mediated pathways. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Grewia asiatica fruit en_US
dc.subject hypertension en_US
dc.subject vasodilation en_US
dc.subject NO- mediated en_US
dc.subject Ca++ influx en_US
dc.title Pharmacological basis for the antihypertensive activity of Grewia asiatica fruit extract en_US
dc.type Article en_US


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