Abstract:
Many pharmacological activities have been reported from plants polyphenols. The aim of this study was to
investigate anti inflammatory and antinociceptive activities of polyphenols from Feijoa sellowiana fruit and leaves. For
the anti-inflammatory activity evaluation, inhibition of carrageenan induced edema was used. While for the evaluation of
antinociceptive activity of the extract, writhing and hot plate tests in mice were used. Impairment in mouse coordination
was evaluated by rota-rode test. Carrageenan induced edema was significantly inhibited by the extract at 50-400 mg kg-1
doses, when comparison was made with control group. The extract of leaf at the dose of 50 mg kg-1 i.p. the activity was
equipotent with diclofenac (p>0.05). Extract reduced the writhing count in 50-400 mg kg-1 of doses. Fruit extract showed
higher activity than diclofenac (p<0.001) at 400 mg kg-1 doses. In all tested doses, the extract significantly augmented the
pain threshold in hot plate thermal test. No locomotor impairment in mice was induced by the extract at any tested doses.
Extract was safe and didnot demonstrate any noxiousness up to 1 g kg-1.This study indicates the potential therapeutic use
of Feijoa as a potent anti-inflammatory and antinociceptive agent.
