PASTIC Dspace Repository

Anti-inflammatory and anti-nociceptive activities of polyphenols from Feijoa fruit and leaves

Show simple item record

dc.contributor.author Mahmoudi, Mitra
dc.contributor.author Seif, Sadaf
dc.contributor.author Khan, Barkat Ali
dc.contributor.author Alshahrani, Sultan M
dc.contributor.author Arimi, Amirali
dc.contributor.author Allami, Alireza
dc.contributor.author Alqahtani, Saad S.
dc.contributor.author Ebrahimzadeh, Mohammad Ali
dc.date.accessioned 2022-10-19T05:36:57Z
dc.date.available 2022-10-19T05:36:57Z
dc.date.issued 2021-07-20
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13264
dc.description.abstract Many pharmacological activities have been reported from plants polyphenols. The aim of this study was to investigate anti inflammatory and antinociceptive activities of polyphenols from Feijoa sellowiana fruit and leaves. For the anti-inflammatory activity evaluation, inhibition of carrageenan induced edema was used. While for the evaluation of antinociceptive activity of the extract, writhing and hot plate tests in mice were used. Impairment in mouse coordination was evaluated by rota-rode test. Carrageenan induced edema was significantly inhibited by the extract at 50-400 mg kg-1 doses, when comparison was made with control group. The extract of leaf at the dose of 50 mg kg-1 i.p. the activity was equipotent with diclofenac (p>0.05). Extract reduced the writhing count in 50-400 mg kg-1 of doses. Fruit extract showed higher activity than diclofenac (p<0.001) at 400 mg kg-1 doses. In all tested doses, the extract significantly augmented the pain threshold in hot plate thermal test. No locomotor impairment in mice was induced by the extract at any tested doses. Extract was safe and didnot demonstrate any noxiousness up to 1 g kg-1.This study indicates the potential therapeutic use of Feijoa as a potent anti-inflammatory and antinociceptive agent. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Carrageenan en_US
dc.subject writhing en_US
dc.subject hot plate en_US
dc.subject locomotor impairment en_US
dc.title Anti-inflammatory and anti-nociceptive activities of polyphenols from Feijoa fruit and leaves en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account