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Insights into Off-Label therapeutic strategies against mild and severe COVID-19 infection

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dc.contributor.author Arshad, Bushra
dc.contributor.author Iqbal, Tahira
dc.contributor.author Bhatti, Khalid Pervez
dc.contributor.author Ahmed, Sheraz
dc.contributor.author Zaman, Wajid
dc.contributor.author Fazal Ullah
dc.contributor.author Nazeer, Amna
dc.contributor.author Saqib, Saddam
dc.date.accessioned 2022-10-19T06:00:56Z
dc.date.available 2022-10-19T06:00:56Z
dc.date.issued 2021-07-20
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13273
dc.description.abstract Currently, prevention and control of the coronavirus disease pneumonia epidemic situation are grim globally. To cope with total sheer carriers and patients of COVID-19 requires intensive medical support and adjunctive therapies to overcome the disease. The epidemic can be controlled with the help of both, disease suppression via community health measures and adjunctive therapies for patients suffering from infection. Till date, we do not have any proper antiCOVID-19 therapy. In order to achieve the overall realization of this pandemic, there is a need to identify treatments depending upon their direct or indirect targets; like inhibition of polyprotein synthesis, transmembrane serine protease, inhibition of viral entry and endocytosis. This could be possible by turning the focus in the direction towards the development of numerous tentative drugs, particularly in the severe to badly ill. Though, majority of these off-label adjunctive medicines are being inspected in a lot of clinical trials at different stages, scientific organizations have endeavored to elucidate the situation where these adjunctive drugs might be practiced as off-label, open- label or compassionate. Our review compiles the adjunctive therapies adopted in COVID-19 infected patients according to clinical severity in conjugation with practicing recommendations from existing guidance rules issued by global professional bodies in healthcare. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject COVID-19 en_US
dc.subject epidemic en_US
dc.subject polyprotein synthesis en_US
dc.subject therapies en_US
dc.subject healthcare en_US
dc.title Insights into Off-Label therapeutic strategies against mild and severe COVID-19 infection en_US
dc.type Article en_US


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