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Genome wide association study and phylogenetic analysis of novel SARS-COV-2 virus among different countries

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dc.contributor.author Ahmad, Syed Umair
dc.contributor.author Khan, Muhammad Shehzad
dc.contributor.author Jan, Zainab
dc.contributor.author Khan, Nayab
dc.contributor.author Ali, Asif
dc.contributor.author Rehman, Naumana
dc.contributor.author Haq, Mohsina
dc.contributor.author Khan, Umama
dc.contributor.author Bashir, Zohaib
dc.contributor.author Tayyab, Muhammad
dc.contributor.author Haq, Ihteshamul
dc.contributor.author Bakht, Shumaila
dc.contributor.author Zahir, Fazli
dc.date.accessioned 2022-10-19T06:01:34Z
dc.date.available 2022-10-19T06:01:34Z
dc.date.issued 2021-07-20
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13275
dc.description.abstract Corona Virus (COVID-19) outbreak has threatened the world, since it has become pandemic and spread all over the world. The causative agent SARS-COV2 has proved lethal caused serious public health concern worldwide. Our aims were to describe the SARS-COV-2 genetic connections and check for recombination of all genome. The recombination was investigated by RDP5 and conflicting phylogenetic clustering in individual genomic fragments was established by phylogenetic study by maximum likelihood and Bayesian methods. Our analysis suggests that the available sequences from currently genomes of various strain were retrieved from different countries including Japan, French Republic, Spain, Peru, China, Vietnam, Taiwan, Brazil, U.S.A., South Korea, Sweden, Australia, Nepal, India, Iran, and Italy. The phylogeny of SARS-COV-2 observed the largest number of genome is Vietnam 29891-bp, while France is the smallest member identified with 29679-bp. Using Recombination Detection program5 (RDP5) the china strains was taken as parental strain but there were no recombination in the all strains. In our study we identified the mutation in Pakistani strains in high conserved region of Corona nucleoca super family domain at the nucleotide position (394: C replace with T, Position: 858: C replace with T and Position: 997 G replace A). en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject SARS-COV-2 en_US
dc.subject strains en_US
dc.subject multiple sequence alignment en_US
dc.subject phylogeny. en_US
dc.subject recombination en_US
dc.title Genome wide association study and phylogenetic analysis of novel SARS-COV-2 virus among different countries en_US
dc.type Article en_US


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