Abstract:
Empagliflozin is a selective inhibitor of sodium glucose co-transporter II, given as mono therapy or an add-on
treatment to reduce the glycated hemoglobin levels in type 2 diabetes. This work deals with designing, formulating and
optimizing empagliflozin (10mg) immediate release (IR) tablets by direct compression technique using different
excipients. Through central composite rotatable design (CCRD), total nine formulations (EF1-EF9) were generated by
changing the composition of binder avicel PH 102®
(X1) and superdisintegrant acdisol®
(X2). Formulation runs with in
suitable weight range and powder properties were subjected to compression. The influence of interaction of excipients
on friability (Y1), hardness (Y2) and disintegration (Y3) were analyzed by fitting the polynomial quadratic model with
response surface methodology (RSM). Trials EF2, EF7, EF8 and EF9 exhibited acceptable tablet attributes upon
physico-chemical testing. Different dissolution models were applied to observe the in vitro drug release pattern in
phosphate buffer of pH 6.8. The cumulative drug release of IR tablet batches followed the Weibull kinetics with
regression coefficient (r
2
) values of 0.983-0.992. Empagliflozin trials were exposed to accelerated storage conditions
(40±2°C/ 75±5% RH) for stability testing. Shelf life period of exposed formulations were computed in range of 22 to 25
months. Keeping in view of the results, it is concluded that the employed technique of preparation and optimization are
observed to be excellent for developing immediate release empagliflozin (10mg) tablets.
