Abstract:
The present work was conceptualized to determine the potential protective effects of curcumin on arsenicinduced kidney damage in male albino rat model. Thirty six male albino rats were selected, weighed about 175±10g and
classified into four groups (9 rats in each group) such as C group (control with basal diet), Cur group (curcumin
200mg/kg body weight), AI group (arsenic-induced 5mg/kg body weight) and AI + Cur group (arsenic
5mg/kg+curcumin 200mg/kg body weight), respectively. Arsenic and curcumin were offered through the gavage method
once daily with basal diet. The different analyzed parameters showed that arsenic-induced elevation of aspartate amino
transferase, alkaline phosphatase, bilirubin urea, alanine aminotransferase and creatinine significantly decreased with
curcumin application in AI + Cur group. Similarly, the statistically significant decline of low-density lipoprotein (LDL),
cholesterol, triglyceride and increased in high-density lipoprotein (HDL) was observed in rats of AI + Cur group with
curcumin treatment as compared to the rats of AI group. The level of different enzymes of the liver as well as kidney was
noted depleted on arsenic exposure whereas increased in level was observed with curcumin application in AI + Cur
group. Moreover, pathological histology changes were also recorded. The outcomes suggest that curcumin has a
potential effect against arsenic-induced toxicity in biological model.
