Abstract:
Coronary artery disease (CAD) and the problems associated with it are the most prominent causes of death in
the whole world. Statins are accustomed to lower lipid levels in CAD patients. The target of this study was to analyze
whether or not common variations in HMGCoA Reductase (HMGCR) and Apolipoprotein E (ApoE) genes are
responsible for metabolism of lipid and statin that modify the impact of statins on serum level of lipids and lipoprotein
concentrations in Coronary heart disease patients. One hundred CAD patients were registered for the study. At the start
of the study biochemical measurements were performed to work out the baseline levels. Patients were treated with
twenty mg Lipitor for one month and biochemical measurements were tested again. According to the post-treatment,
LDL-c levels, patients were divided into a pair of group as non-responders and responders, independently. The
information concerning the risk factors like smoking, alcohol consumption etc. was conjointly obtained. DNA was
extracted from peripheral blood. The presence of rs17244841 and rs17238540 mutations in HMGCR and ε2, ε3 and ε4
variants of ApoE were settled by performing RT-PCR. Results were assessed statistically. HMGCR mutations were
principally found in responders and ε4 variant of ApoE was principally found in non-responders. It was found that the
presence of HMGCR mutations causes a big reduction in total cholesterol and LDL-c levels. Conjointly, the presence of
ε2 variant of Apo E causes a statistically vital increase in triglyceride levels. Our findings should be investigated by
different researchers to clarify the mechanism.
