Abstract:
Non insulin dependent diabetes mellitus (NIDDM) drugs such as glibenclamide and metformin is employed to
heterogeneous disorder characterized by alteration in production of glucose due to impairment of both insulin secretion
and insulin action. These patients might suffer with allergic rhinitis and in this case, there is a possibility to maintain
patient on levocetirizine, an anti-allergic drug commonly used in rhinitis. The object of the present study is to detect
possible interaction between glibenclamide or metformin with levocetirizine Current study was performed using UV
spectroscopic technique sing simultaneous equation in pH simulated to gastric juice (pH 1), pH 4, pH 7.4 and in pH 9.
All drugs followed Beer Lambert’s Law. Results showed that glibenclamide and metformin can increase or decrease
availability of levocetirizine and in the same way levocetirizine can alter availabilities of glibenclamide and metformin in
different pH. Hence, drug interaction between glibenclamide or metformin with levocetirizne occurred. This may be due
to his may be due to the charge transfer or binding capabilities of these drugs which resulted in significantly changed
availability of NIDDIM as well as levocetirizine. Therefore, co-administration of these drugs should be avoided and
furtherinvestigations at clinical and pre-clinical levels should be done.
