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Spectroscopic interactions of non-insulin-dependent diabetes mellitus with levocetirizine

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dc.contributor.author Mehboob, Shafaque
dc.contributor.author Mehboob, Moona
dc.contributor.author Mehjabeen
dc.contributor.author Tariq Rafi, SM
dc.contributor.author Khan, Tariq
dc.contributor.author Anser, Humaira
dc.contributor.author Perveen, Shaheen
dc.contributor.author Jahan, Noor
dc.contributor.author Wazir, Asma
dc.contributor.author Owais, Farah
dc.date.accessioned 2022-10-19T06:08:10Z
dc.date.available 2022-10-19T06:08:10Z
dc.date.issued 2021-07-20
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13293
dc.description.abstract Non insulin dependent diabetes mellitus (NIDDM) drugs such as glibenclamide and metformin is employed to heterogeneous disorder characterized by alteration in production of glucose due to impairment of both insulin secretion and insulin action. These patients might suffer with allergic rhinitis and in this case, there is a possibility to maintain patient on levocetirizine, an anti-allergic drug commonly used in rhinitis. The object of the present study is to detect possible interaction between glibenclamide or metformin with levocetirizine Current study was performed using UV spectroscopic technique sing simultaneous equation in pH simulated to gastric juice (pH 1), pH 4, pH 7.4 and in pH 9. All drugs followed Beer Lambert’s Law. Results showed that glibenclamide and metformin can increase or decrease availability of levocetirizine and in the same way levocetirizine can alter availabilities of glibenclamide and metformin in different pH. Hence, drug interaction between glibenclamide or metformin with levocetirizne occurred. This may be due to his may be due to the charge transfer or binding capabilities of these drugs which resulted in significantly changed availability of NIDDIM as well as levocetirizine. Therefore, co-administration of these drugs should be avoided and furtherinvestigations at clinical and pre-clinical levels should be done. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Non-insulin-dependent diabetes mellitus en_US
dc.subject glibenclamide en_US
dc.subject levocetirizine en_US
dc.subject drug interaction en_US
dc.title Spectroscopic interactions of non-insulin-dependent diabetes mellitus with levocetirizine en_US
dc.type Article en_US


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