Abstract:
: Indomethacin is potent and effective drug belongs to NSAID group having low bioavailability. To address this
issue the novel method is Nanosuspensions which can be achieved through bottom up and top down methods. The drug
concentration, batch size and crystallinity retention are the problems associated with bottom up method consequently top
down method was applied. In current project batch size of 350 ml was prepared by mixing 3.5% of Indomethacin with
polymer solution. Then it was introduced into Dena®
having 0.2µm yttrium reinforced zirconium beads. The effect of
milling time was observed for sixty minutes. Stable nanocrystals with particle size of 161nm ±1.90 with PDI of 0.229
±0.06 were produced. The DSC and PXRD confirmed the crystallinity of created nanocrystals. The pattern of particle
size reduction was initially abrupt and then gradual. The two months Stability studies at 4oC and at 25oC revealed that
polymers combination (PVP-K30, HPMC-6cps, SDS) were effective in marinating the stability. The SEM and TEM
studies unfastened that nanocrystals were homogenously distributed with discrete crystalline morphology. The fabricated
nanocrystals demonstrated marked dissolution rate compared to the raw and marketed formulations. It is demonstrated
that it is useful for industry due to high drug concentration, large batch size and retention of distinct characteristics.
