• Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation 

  Hamid, Hajra Afeera; Khan, Shahzeb; Shah, Syed Muhammad Noor; Asghar, Muhammad; Shahid, Muhammad; Hussain, Zahid; Sohail, Muhammad; Barkat, Ali Khan; Amin, Fazli; Jan, Syed Umer; Elhissi, Abdelbary; Shah, Syed Muhammad Hassan; Minhas, Muhammad Usman; Shah, Syed Wadood Ali; Ahmad, Naveed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Piroxicam (PC) is a non-steroidal anti-inflammatory drug characterized by poor aqueous solubility and reported to cause and impart crucial GIT irritation, bleeding, peptic and duodenal ulcer. Engineering of PC ...
• Cardiotonic potential of Carissa opaca Stapf ex Haines: A study on isolated rabbit heart 

  Alqahtani, Yahya S; Amir, Huma; Alamgeer; Ahmad, Taseer; Mahnashi, Mater H; Alyami, Bandar A; Alqarni, Ali O; Akram, Muhammad; Khan, Hafeez Ullah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  : Carissa opaca (C.O) is a wild shrub, belonging to the family Apocynaceae. The medicinal virtues of this plant have long been known. The present study demonstrates the effects of aqueous-methanolic extract and various ...
• Cardioprotective effect of boswellic acids against doxorubicin induced myocardial infarction in rats 

  Shahid, Muhammad Hassaan; Anjum, Irfan; Mushtaq, Muhammad Naveed; Riaz, Saba (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The aim of the present study was to evaluate the cardioprotective activity of boswellic acids in doxorubicin (DOX) induced cardiotoxicity. DOX (2.5mg/kg) was used intraperitoneally in rats to induce cardiotoxicity in six ...
• Synthesis and anticancer evaluation of 2-oxo-2-(arylamino) ethyl 4- phenylpiperazine-1-carbodithioates 

  Hafeez, Freeha; Zahoor, Ameer Fawad; Rasul, Azhar; Ahmad, Sajjad; Mansha, Asim (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Piperazine moiety is found as an efficient pharmacological scaffold in various drugs. To explore the anticancer potential of piperazine framework, a series of novel N-acetamides derivatives of phenyl piperazine ...
• Immunoinformatics approaches to explore B and T cell epitope-based vaccine designing for SARS-CoV-2 Virus 

  Bashir, Zohaib; Ahmad, Syed Umair; Kiani, Bushra Hafeez; Jan, Zainab; Khan, Nayab; Khan, Umama; Ihteshamul Haq; Zahir, Fazli; Qadus, Amara; Mahmood, Tariq (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  SARS-CoV-2, a new world coronavirus belonging to class Nidovirales of Coronaviridae family causes COVID-19 infection which is the leading cause of death worldwide. Currently there are no approved drugs and vaccines available ...
• Potential therapeutic effects of avenanthramide-C against lung toxicity caused by silver nanoparticles injection in rats 

  Altwaijry, Najla; El-Masry, Thanaa A; Alotaibi, Badriyah S; Tousson, Ehab; Alodhayani, Abdulaziz A; El-Morshedy, Kadreya; Elmaghed, Nouf A; Sayed, Ahmed E; Saleh, Asmaa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  : Most clinical investigations about the impact of nanoparticles on cells and tissues show that nanoparticles may enter the human body by means of respiratory tracts. Humans, animals, plants and environments are ...
• Less disease severity of COVID-19 among smokers: An indication of investigating nicotine as preventive measure 

  Ghayyur, Aysha; Hussain, Syed Shahzad; Salam, Emaan; Saeed, Subhan; Shahid, Saman; Tanvir Us Salaam (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The study was aimed to mention the epidemiology of smoking in Pakistani COVID-19 infected patients along with the disease severity, oxygen dependency and fatality rate. A cross sectional epidemiological study was carried ...
• Oral bioavailability studies of niosomal formulations of Cyclosporine A in albino rabbits 

  Mujeeb Ur Rehman; Rasul, Akhtar; Khan, Muhammad Imran; Rasool, Maria; Abbas, Ghulam; Masood, Feroza; Nazir, Imran; Iqbal, Muhammad; Islam, Nayyer; Hameed, Misbah; Shah, Pervaiz Akhtar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Cyclosporine A (CsA) is an immunosuppressant agent. Two niosomal formulations of CsA, FTS and FSB were formulated. Both formulations were studied in terms of size, polydispersity index (PDI), morphology and entrapment efficacy ...
• Hepatoprotective and hypolipidemic activities of Caesalpinia bonduc seed kernels and Gymnema sylvestre leaves extracts in alloxan-induced diabetic rats 

  Kousar, Shaneel; Aslam, Bilal; Muhammad, Faqir; Khan, Junaid Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The objective of the current research was to validate the hepatoprotective and anti-hyperlipidemic activities of C. bonduc seed kernels (CBSK) and G. sylvestre leaves (GSL) hydro-methanolic extracts, separately and in ...
• In vitro antioxidant potential and antiproliferative activity of Aesculus indica seed extract against hepatocellular carcinoma cell line 

  Shahbaz, Hina; Latif, Abida; Perveen, Sadia; Hussain, Khalid; Azam, Shamaila; Shaukat, Ayisha; Bukari, Nadeem Irfan; Tayyeb, Asima (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Therapeutic secondary metabolites have gained immense attention in recent years due to their effective medicinal properties. Aesculus indica is a medicinally important plant being traditionally used for various ailments. ...
• GC-MS analysis, anticancer and anti-inflammatory activities of Saussurea hypoleuca spreng. Root 

  Arshad, Numera; Ishtiaq, Saiqa; Khan, Farrakh Zia; Danish, Zeeshan; Rashid, Ahmad Junaid; Ijaz, Bushra; Tariq, Somayya (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Study has been premeditated to appraise the anticancer and anti-inflammatory activities of a native medicinal plant Saussurea hypoleuca Spreng root. Anticancer assays including MTT, Alamar Blue (AB), Neutral Red (NR) ...
• Effectuation of loading a natural acetyl carnosine derivative within a promising cross-linked cyclodextrin spongey-like nanospheres on Physicochemical characterization and release behavior 

  Badawi, Alia; Mohammed, Magdy; Khalil, Rawia; Ali, Ruddy; Taleb, Sally Abou (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  This study centered on the ability of the cross-linked nano-sponge system to load the drug and to improve its physicochemical and dissolution properties. A spectrophotometric method was used to determine the wavelength ...
• Clinical and biochemical indicators of disease severity and neurological findings in COVID-19: A study of King Edward Medical University (KEMU), Pakistan 

  Iftikhar, Sadaf; Ghias, Mamoona; Shahid, Saman; Ali, Muhammad Rashid; Hassan, Muhammad Umar; Numan, Ahsan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  This study investigated the significance of difference between presence and absence of different neurological findings in COVID-19, in relation with the biochemistry. Various significant correlations in connection with ...
• Acacia modesta attenuates MnCl2 induced hepatotoxicity, oxidative stress and hepatic inflammation in wistar rats 

  Abid, Farah; Saleem, Muhammad; Zaidi, Awais Ali; Mobashar, Aisha; Yasir, Saliha (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Natural Plants are broadly used in treating inflammatory disorders. The current study focused on evaluating the hepato-protective and anti-inflammatory potential of A. modesta in MnCL2 induced hepatotoxicity and ...
• Appraisal of anti-mycobacterial potential against MDR-MTB in pediatric patients, cytotoxicity and mutagenicity of Aloe vera and Allium sativum 

  Iqbal, Aqeela; Ashraf, Muhammad; Rathore, Ahsan Waheed; Omer, Muhammad Ovais; Anjum, Aftab Ahmad; Bano, Iqbal; Ali, Muhammad Asad; Ali, Rana Adnan; Hafeez Ullah; Zaman, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The purpose of the studies was to evaluate an in-vitro anti-mycobacterial activity of Aloe vera and Allium sativum against MDR-MTB, their cytotoxicity and mutagenicity. Four extracts of Aloe vera and Allium sativum ...
• Formulation and optimization of dimenhydrinate emulgels for topical delivery using response surface methodology 

  Khan, Qalander; Shah, Syed Nisar Hussain; Arshad, Muhammad Sohail; Usman, Faisal; Khalil, Ruqaiya; Zaheer Ul-Haq; Siddiqui, Faheem Ahmed; Hussain, Talib; Yousaf, Abid Mehmood; AA Rizvi, Syed; Shahzad, Yasser (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Development of dimenhydrinate (DMN) emulgel formulation has been described in this work with enhanced permeation for transdermal delivery of DMN for effective management of motion sickness. Various DMN emulgel formulations ...
• Antibacterial efficacy of silver nanoparticles against metallo-βlactamase (blaNDM, blaVIM, blaOXA) producing clinically isolated Pseudomonas aeruginosa 

  Qureshi, Rabia; Qamar, Muhammad Usman; Shafique, Muhammad; Muzammil, Saima; Rasool, Muhammad Hidayat; Ahmad, Ijaz; Ejaz, Hasan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Carbapenem resistance in Pseudomonas aeruginosa is a major concern in the public health sector, primarily in developing countries such as Pakistan. Therefore, novel approaches such as Silver nanoparticles (AgNPs) can be ...
• Development and Quality evaluation of sustained release pellets of eperisone HCl 

  Jawed, Syed Hameez; Muhammad, Iyad Naeem; Qazi, Faiza; Shoaib, Muhammad Harris; Arshad, Hafiz Muhammad; Siddiqui, Tuba (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The objective was to develop eperisone HCl sustained-release pellets through extrusion spheronization technique and to determine the influence of different hydrophobic (polymeric based and wax-based) and hydrophilic (polymeric ...
• Antiviral activity of hexapeptides derived from conserved regions of bacterial proteases against HCV NS3 protease 

  Mushtaq, Amna; Ghulam Mustafa; Ansari, Tariq Mahmood; Shad, Muhammad Aslam; Cruz-Reyes, Jorge; Jamil, Amer (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The main cause of hepatitis C is hepatitis C virus or HCV and for the cure of hepatitis C, NS3/4A protease has been found an important and emerging target. A number of HCV NS3/4A protease inhibitors have been discovered which ...
• Development, characterization and optimization of methotrexate-olive oil nano-emulsion for topical application 

  Sheikh Abdur Rashid; Bashir, Sajid; Hashmat Ullah; Kifayat ullah Shah; Khan, Daulat Haleem; Shah, Pervaiz Akhtar; Danish, Muhammad Zeeshan; Khan, Muhammad Hashim; Mahmood, Saima; Sohaib, Muhammad; Irfan, Malik Muhammad; Amin, Adnan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The chronic inflammatory conditions like psoriasis has an increased prevalence and is linked with various associated life threatening disease conditions. The main objective of this project was to developed a methotrexat ...

View more