• Nanobiotechnology: Cradle for revolution in drug carrier systems 

  Zafar, Saba; Rasul, Akhtar; Iqbal, Muhammad Shahid; Rasool, Maria; Ahmed, Bilal; Qadir, Muhammad Imran (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  : The role of nanobiotechnology in the treatment of diseases is limitless. In this review we tried to focus main aspects of nanotechnology in drug carrier systems for treatment and diagnosis of various diseases such as ...
• Role of Kisspeptin-GPR54 system in regulation of reproductive functions in human and other mammals 

  Ilahi, Ikram; Taqweem Ul Haq (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Kisspeptin is a 54- amino acid peptide that acts as a ligand of a receptor called GPR54 which is basically a transmembrane receptor that spins seven times across the cell membrane and coupled with G-protein. Kisspeptin regulates ...
• IR study of degradation of acetaminophen by iron nano-structured catalyst 

  Altaf, Iqbal; Azmat, Rafia (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Full degradation of acetaminophen (paracetamol) in aqueous solution was investigated at room temperature through heterogeneous iron nano-structured as catalyst in this article. Iron Nano-structured was prepared through ...
• Salicylic acid attenuates gentamicin-induced nephrotoxicity in rabbits 

  Zaidi, Syeda Nuzhat Fatimah; Usman, Sheikh Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Gentamicin (GM) is a generally utilized as an antibiotic against dangerous and life threatening contaminations, yet its value is restricted by the development of nephrotoxicity. The present investigation was intended to ...
• 3,4-dihydroxyacetophenone inhibits hypoxia-associated human pulmonary artery smooth muscle cell proliferation by reducing Ca2+ influx 

  Lin, Chunlong; Li, Caixia; Zhao, Jianping; Ni, Wang; Yi, Jizu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The present study aimed to assess the effects of 3,4-dihydroxyacetophenone (DHAP) on human pulmonary artery smooth muscle cells (HPASMCs). HPASMCs were divided into the normoxia group (NG), hypoxia group (HG), and hypoxia ...
• Phytochemical screening and biological activities of Bromus pectinatus Thunb 

  Begum, Kausar; Abbas, Saira; Mushtaq, Nadia; Khan, Saad Ullah; Parveen, Ishrat; Jamil ur Rahman, H.; Mahmood, Sultan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The present research study investigates the phytochemical and pharmacological importance of Bromus pectinatus. Qualitative phytochemical analysis of this plant was carried out to use standard method for the presence ...
• Effects of shikonin from Zicao on high-fat diet-induced nonalcoholic fatty liver disease in rats 

  Yang, Weijia; Yang, Minchun; Yao, Hui; Ma, Yelin; Ren, Xuanxuan; Teng, Long; Wang, Tao (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  In this study, we aim to investigate whether shikonin prevents against NAFLD. After feeding high-fat diet (HFD) for 10 weeks, Sprague-Dawley rats were received different doses of shikonin (5mg/kg/day, 10mg/kg/day ...
• Neurochemical and behavioral effects of lorazepam: A dose related study 

  Ikram, Huma; Atique, Iqra; Perveen, Shahla; Zakir, Rumaisa; Haleem, Darakhshan J (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Present study was designed to monitor the dose dependent effects of lorazepam; a benzodiazepine (CNS depressant). It is the primary drug of choice for treatment of anxiety and to produce calming effects. However, ...
• Effects of glycosaminoglycan from Urechis unicinctus on the P2Y1 receptor pathway and expression of related factors in rat platelets 

  Yuan, Chunying; Gao, Tong; Li, Jinghong; Cui, Qingman (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The aim of this study was to examine the effects of glycosaminoglycan (GAG) from Urechis unicinctus on the P2Y1 receptor pathway and expression of related factors in rat platelets. The concentration of calcium ion (Ca2+) ...
• Electrochemical oxidation of amoxicillin, ciprofloxacin and erythromycin in water: Effect of experimental factors on COD removal 

  Firdaus, Irum; Yaqub, Asim; Ajab, Huma; Khan, Imran; Amin, Bilal Ahmed Zafar; Baig, Ayesha; Isa, Mohamed Hasnain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  An alternative method of electrochemical oxidation was employed to degrade persistent compounds in the form of antibiotics using strong oxidizing agents such as hydroxyl ions. A 24 factorial design was employed to check ...
• Dissolution monitoring of diclofenac sodium and codeine phosphate tablets using fibre optic chemical sensor assisted by dual-wavelength isosbestic point spectrophotometry 

  Zhang, Lu; Lu, Chunhui; Li, Xinxia; Li, Jianguang (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The purpose of this investigation was to establish a mathematical model for determining the dissolution of diclofenac sodium and codeine phosphate simultaneously. Based on the dual-wavelength isosbestic point spectrophotometry, ...
• Association of BDNF and SERT gene polymorphisms with depression among Pakistani population 

  Akhter, Naheed; Iqbal, Mehir un Nisa; Maqsood, Aliya; Sheikh, Safdar Ali; Ali, Anwar; Khan, Taseer Ahmed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Brain-derived neurotrophic factor (BDNF) and serotonin transporter (SERT) is implicated in the adverse life events which lead to depression. The variation in genetic make-up of BDNF (Val66Met) and SERT (5’-HTTLPR) ...
• Association of BDNF and SERT gene polymorphisms with depression among Pakistani population 

  Akhter, Naheed; Iqbal, Mehir un Nisa; Maqsood, Aliya; Sheikh, Safdar Ali; Ali, Anwar; Khan, Taseer Ahmed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Brain-derived neurotrophic factor (BDNF) and serotonin transporter (SERT) is implicated in the adverse life events which lead to depression. The variation in genetic make-up of BDNF (Val66Met) and SERT (5’-HTTLPR) ...
• Effect of melittin on iNOS and NF-κB expression induced by IL-1βin C518 cells 

  Tang, Faqiang; Wu, Hong; Zheng, Jianzhang; Guo, Huiling; Yan, Laipeng; Lin, Yunshuo; Xu, Chuncai; hu, Shiping (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Melittin (Mel), a natural detergent, is a major component of bee venom. Mel exhibits favorable clinical effects on the treatment of rheumatoid osteoarthritis, myositis, lumbar muscle strain, and peripheral neurological ...
• Phenotypic and molecular characterization of virulence factors of extra-intestinal pathogenic Escherichia coli isolated from patients of Peshawar, Pakistan 

  Zeb, Zermina; Azam, Sadiq; Rehman, Noor; Khan, Ibrar; Afzal, Sumera; Gul-e-Sehra; Anhar Ullah; Absar, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Extra-Intestinal Escherichia coli (ExPEC) are important cause of Urinary Tract Infections (UTIs) and systemic infections. The purpose of this study was to investigate numerous ExPEC bacterial isolates for phenotypic virulence ...
• Skin-whitening mechanism of cumin (Cuminum cyminum L.) extract 

  Wang, Ya; Du, Guo-Ying; Guo, Tao; Zou, Hong-Mei; Jia, Dan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Skin-whitening effect is closely linked with the melanogenesis inhibitory activity and free radical scavenging capacity. The purpose of the present study was to evaluate the skin-whitening effect of cumin (Cuminum cyminum ...
• Therapeutic role of Rauwolfia serpentina in minimizing the risk of glycosylation and associated biomarkers in experimentally induced type 1 diabetic mice 

  Azmi, Muhammad Bilal; Qureshi, Shamim Akhtar; Ahmed, Syed Danish Haseen; Khan, Auwais Ahmed; Ahsan, Muhammad; Mudassir, Hina Akram; Imtiaz, Fauzia; Rais, Sumera (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Present work investigates the effects of hydro-methanolic roots extract (HyMREt) of Rauwolfia serpentina in type 1 diabetic mice. Mice were divided into normal, diabetic, negative and positive controls (I-IV) and three ...
• Clinical effect of intrathecal injection of medicine combined with continuous lumbar cistern drainage on intracranial infection after intracranial tumor surgery 

  Wang, Jialiang; Liu, Haipeng; Zheng, Kebin; Zhang, Shuai; Dong, Wei (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  This study was designed to scrutinize the clinical effectiveness of intrathecal injection of medicine along with constant lumbar cistern drainage on intracranial infection subsequent to intracranial tumor operation. Sixty ...
• Formulation development and in-vitro evaluation of gastroretentive drug delivery system of loxoprofen sodium: A natural excipients based approach 

  Zaman, Muhammad; Akhtar, Faiza; Abdul Baseer; Hasan, Syed Muhammad Farid; Aman, Waqar; Khan, Amjad; Badshah, Munair; Majeedullah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  The limitations of conventional type delivery systems to retain drug (s) in the stomach has resulted in the development of novel gastroretentive drug delivery system. We developed single-layer effervescent floating tablets ...
• Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka 

  Hassan, Ibrahim Maina; Ibrahim, Wan Norhamidah Wan; Yusuf, Ferdaus Mohamat; Ahmad, Siti Aqlima; Ahmad, Syahida (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)

  Diseases caused by oxidative stress can be prevented by antioxidant. Current treatments for those neurodegenerative diseases are not effective and cause many side effects. Thus, the search for alternative medicines is ...

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