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Antifungal potency of Nigella sativa against toxigenic Rhizopus stolonifer and its immunomodulatory effects in aflatoxin-fed mice

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dc.contributor.author Othman, Gehan Ahmed
dc.contributor.author Alghamdi, Huda Ahmed
dc.contributor.author Abd El Moneim Ahmed, Dalia
dc.contributor.author Mahmoud Radwan, Asmaa
dc.date.accessioned 2022-10-19T07:18:24Z
dc.date.available 2022-10-19T07:18:24Z
dc.date.issued 2019-07-24
dc.identifier.citation Othman, G. A., Alghamdi, H. A., Ahmed, D. A. E. M., & Radwan, A. M. (2019). Antifungal potency of Nigella sativa against toxigenic Rhizopus stolonifer and its immunomodulatory effects in aflatoxin-fed mice. Pakistan Journal of Pharmaceutical Sciences, 32(4SI), 1849-1855. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13330
dc.description.abstract The present study describes the antifungal potency of Nigella sativa seeds extract and the effect of immunomodulatory of N. sativa against aflatoxin- fed mice. Disc diffusion method was used for antifungal efficacy of aqueous extract of N. sativa. In animal experiments, lymphoid cell count, total and differential counts of PEC, the phagocytic activity of PEC and detection of the plaque-forming were determined. E-rosette-forming cells (RFC), T-cell mitogenesis assay cells, ALT and AST were detected. The aqueous extract of N. sativa (50%) exhibited high inhibition zone with most of isolates of R. stolonifera.The results indicated that treatment of mice by using N. sativa showed marked rise in the number of cells from thymus and PLN with dose 0.50 g and absolute number and comparative ratio of macrophages (P < 0.01) with the doses 0.40 and 0.50 g. There is gradually rise in the scavenger activity of PEC with the dose 0.50 g at 60 min. Serum level of ALT was markedly reduced with dose 0.50 g as compared with a control group. These results indicated that N. sativa is promising modifier of biological response. en_US
dc.language.iso en_US en_US
dc.subject Aflatoxin en_US
dc.subject Nigella sativa, en_US
dc.subject lymphocytes en_US
dc.subject T-cells en_US
dc.subject B-cells en_US
dc.subject macrophages en_US
dc.subject liver enzymes-spleen cell en_US
dc.title Antifungal potency of Nigella sativa against toxigenic Rhizopus stolonifer and its immunomodulatory effects in aflatoxin-fed mice en_US
dc.type Article en_US


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