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Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies

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dc.contributor.author Akram, Ayesha
dc.contributor.author Akhtar, Naveed
dc.contributor.author Waqas, Muhammad Khurram
dc.contributor.author Rasul, Akhtar
dc.contributor.author Rehman, Kashif ur
dc.contributor.author Khan, Jahangir
dc.contributor.author Iqbal, Muhammad
dc.contributor.author Khan, Barkat Ali
dc.date.accessioned 2022-10-19T07:21:51Z
dc.date.available 2022-10-19T07:21:51Z
dc.date.issued 2019-07-26
dc.identifier.citation Akram, A., Akhtar, N., Waqas, M. K., Rasul, A., ur Rehman, K., Khan, J., ... & Khan, B. A. (2019). Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies. Pakistan Journal of Pharmaceutical Sciences, 32(4SI), 1873-1878. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13335
dc.description.abstract Zingeber officinale (ginger) has been used for a long time in conventional medicine for the management of many diseases most important of which is inflammatory diseases. The aim of this study was formulation of topical microemulsion system to enhance the solubility, stability and release profile of ginger extract, as it is unstable in the presence of light, air, heat and long term storage. The solubility of ginger extract in different oils, surfactants, and cosurfactants was determined in order to find the optimal components for microemulsion. Isopropyl myristate (IPM) was selected as oil phase, tween 80 and PEG 400 were selected as surfactant and co-surfactant respectively based on highest solubility values. Pseudo-ternary phase diagram was constructed in order to find out the microemulsion region. The prepared microemulsions were evaluated for pH, viscosity, conductivity, refractive index, globular size, zeta potential, polydispersity index, ginger extract content, in-vitro and ex-vivo release profiles. The formulation GE1 showed best physicochemical properties with smallest globular size (19.75nm), highest release rate and flux value. It also showed significant (p<0.05) anti-inflammatory effect as compared to reference piroxicam drug solution. It is concluded that ginger extract can be used to develop stable microemulsion system with better skin permeation and promising antiinflammatory activity. en_US
dc.language.iso en_US en_US
dc.subject Ginger extract en_US
dc.subject O/W microemulsion en_US
dc.subject pseudo-ternary phase diagram en_US
dc.subject drug release en_US
dc.subject permeability en_US
dc.title Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies en_US
dc.type Article en_US


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