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Promising effects of Rosa damascena petal extracts as antioxidant and antibacterial agents

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dc.contributor.author Ramdan, Btissam
dc.contributor.author Mrid, Reda Ben
dc.contributor.author Ramdan, Rajae
dc.contributor.author Karbane, Miloud El
dc.contributor.author Nhiri, Mohamed
dc.date.accessioned 2022-10-19T07:23:02Z
dc.date.available 2022-10-19T07:23:02Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13337
dc.description.abstract : In the present work, the antioxidant properties of methanolic (MeOH), ethyl acetate (EtOAc) and chloroformic (CHCl3) fractions of Rosa damascena petals were evaluated. Antioxidant capacity was assessed by free radical scavenging assays (DPPH•) and ferrous ions (Fe2+) chelating activity. Antibacterial activity was evaluated using minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and IC50. Qualitative analysis of chemical composition was carried out by HPLC and showed variability in the chemical constituents with a richness in flavonones and phenolic acids. Acute toxicity study and hemolysis test were also assessed. The MeOH and EtOAc fractions are of real and potential interest by their antioxidant activities. Furthermore, the microbiological study of the fractions showed a high activity of the EtOAc fraction which possesses bactericidal properties, followed by a moderate activity of the methanolic MeOH. The most sensitive strains were S. aureus and B. cereus while the most resistant were P. aeruginosa and E. coli (R). On the other side, no cytotoxicity was observed towards erythrocytes isolated from human blood and on a warm-blooded animal model. Therefore, the R. damascena petals constitute a promising source of molecules for clinical use without cytoxicity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Rosa damascena en_US
dc.subject antimicrobial activity en_US
dc.subject cytotoxicity en_US
dc.subject toxicity en_US
dc.subject HPLC en_US
dc.subject antioxidant activity en_US
dc.title Promising effects of Rosa damascena petal extracts as antioxidant and antibacterial agents en_US
dc.type Article en_US


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