Abstract:
A novel series of 5-(3-Chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives
was efficiently synthesized and screened for antibacterial, hemolytic and thrombolytic activities. The molecule 7c
remained the best inhibitor of all selected bacterial strains and furthermore possessed very low toxicity, 8.52±0.31.
Compound 7a 7b and 7f showed very good thrombolytic activity relative to Streptokinase employed as reference drug. In
addition to low toxicity and moderately good thrombolytic activity, the synthesized compounds possessed excellent to
moderate antibacterial activity, relative to ciprofloxacin. All compounds especially 7b and 7f can be consider for further
clinical studies and might be helpful in synthesis of new drugs for treatment of cardiovascular diseases.
