Abstract:
The limitations of conventional type delivery systems to retain drug (s) in the stomach has resulted in the
development of novel gastroretentive drug delivery system. We developed single-layer effervescent floating tablets of
loxoprofen sodium for prolong delivery in the stomach using natural polymers xanthan gum, guar gum and semisynthetic
polymer HPMCK4M. All the formulations (F1-F9) were developed by varying concentrations of xanthan gum and
HPMCK4M while guar gum concentration was kept constant. Two gas generating agent (s) incorporated were sodium
bicarbonate and citric acid. All compendial pre and post-compression tests results were in the acceptable limits. FTIR
analysis confirmed drug-polymer compatibility. The in-vitro drug release in simulated conditions i.e., 0.1 N HCl for 12 h
revealed orderly increase in total floating time, i.e., less than 6 h for F1 over 12 h for F9. Formulations F1 to F4 were not
capable to retard drug release up to 12 h, whereas F5-F7 for 12 h, while F8 and F9 for more than 12 h. Data fitting in
various kinetic models showed that drug release best fit in first order kinetic model and F9 in zero order. Based on results
data, F7 was the best among all.
