Abstract:
This study was designed to scrutinize the clinical effectiveness of intrathecal injection of medicine along with
constant lumbar cistern drainage on intracranial infection subsequent to intracranial tumor operation. Sixty two patients
with intracranial infection after intracranial tumor surgery were selected as the objects of study divided into combined
treatment group (n=31) and the control group (n=31) according to the time of admission. Patients in the combined
treatment group were treated with intrathecal injection of medicine combined with group’s continuous lumbar cistern
drainage while patients in the control group were just treated with intravenous antibiotic therapy followed by comparison
in the clinical efficacy, infection control, the level of inflammatory factor like crp, IL-4 and incidence of complication in
the two groups were compared respectively. The total effectiveness rate was 96.77% in the combined treatment group
and 80.65% in the control group indicating statistical significant difference (p<0.05). The average time of infection
control in the combined treatment group and the control group was 9.05±2.08 and 17.07±3.34 days respectively. After
treatment, the restoration effect of serum crp and IL-4 in the combined treatment group was better (p<0.05). The
complication incidence of patients in the combined treatment group was 3.23% while it was 16.13% in the control group.
Therefore, the difference between the two groups was statistically significant (p<0.05).This advanced combination
therapy proved to be effective as the total clinical efficacy was relatively high. Moreover, the combination therapy also
shortened the time of infection control with lesser complication rate and reduce inflammatory factor.
