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Skin-whitening mechanism of cumin (Cuminum cyminum L.) extract

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dc.contributor.author Wang, Ya
dc.contributor.author Du, Guo-Ying
dc.contributor.author Guo, Tao
dc.contributor.author Zou, Hong-Mei
dc.contributor.author Jia, Dan
dc.date.accessioned 2022-10-20T09:50:31Z
dc.date.available 2022-10-20T09:50:31Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13410
dc.description.abstract Skin-whitening effect is closely linked with the melanogenesis inhibitory activity and free radical scavenging capacity. The purpose of the present study was to evaluate the skin-whitening effect of cumin (Cuminum cyminum L.) extract. The whitening activity was evaluated by cell-free mushroom tyrosinase assay, free radical scavenging assay, cell viability assay, cellular tyrosinase assay and melanin content assay using B16F10 murine melanoma cells. The results showed that cumin extract exhibited concentration-dependent inhibitory effect on both monophenolase and diphenolase activities of mushroom tyrosinase (IC50 values of 1.027mg/mL and 0.977mg/mL, respectively). Kinetic study on diphenolase showed that the cumin extract was a reversible mixed-type inhibitor, and the inhibition constant (KI) was determined to be 0.62mg/mL. In addition, cumin extract significantly suppressed melanin production and cellular tyrosinase activity of B16F10 melanoma cells in a concentration and time dependent manner without cytotoxicity. Moreover, cumin extract exerted strong scavenging capacity on DPPH, hydroxyl and superoxide anion radicals. Taken together, these results strongly suggest that cumin is a potential skin-whitening agent for the cosmetic industry. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Cumin extract en_US
dc.subject melanin synthesis en_US
dc.subject tyrosinase activity en_US
dc.subject free radical scavenging activity en_US
dc.subject kinetic study en_US
dc.title Skin-whitening mechanism of cumin (Cuminum cyminum L.) extract en_US
dc.type Article en_US


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