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Dissolution monitoring of diclofenac sodium and codeine phosphate tablets using fibre optic chemical sensor assisted by dual-wavelength isosbestic point spectrophotometry

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dc.contributor.author Zhang, Lu
dc.contributor.author Lu, Chunhui
dc.contributor.author Li, Xinxia
dc.contributor.author Li, Jianguang
dc.date.accessioned 2022-10-20T09:53:25Z
dc.date.available 2022-10-20T09:53:25Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13420
dc.description.abstract The purpose of this investigation was to establish a mathematical model for determining the dissolution of diclofenac sodium and codeine phosphate simultaneously. Based on the dual-wavelength isosbestic point spectrophotometry, the dissolution of diclofenac sodium and codeine phosphate tablets was determined using Fiber-Optic Dissolution Test (FODT) instrument capable of real-time measurement. Dissolution curves showed that the dissolution process of diclofenac sodium was similar to that of codeine phosphate. The dissolution profile of diclofenac sodium and codeine phosphate at 45 min was concordant with that stated in Chinese pharmacopoeia. There was no significant difference between results obtained from FODT and HPLC (p>0.05). A fibre-optic dissolution test system assisted by the mathematical separation model of linear equations was able to detect the dissolution of diclofenac sodium and codeine phosphate simultaneously. The dissolution profiles and overall data, which can directly reflect the dissolution speed at each time point, can provide the basis for establishing standards for the quality evaluation of drugs. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Dissolution en_US
dc.subject fibre optic en_US
dc.subject dual-wavelength en_US
dc.subject real-time en_US
dc.title Dissolution monitoring of diclofenac sodium and codeine phosphate tablets using fibre optic chemical sensor assisted by dual-wavelength isosbestic point spectrophotometry en_US
dc.type Article en_US


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