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Neurochemical and behavioral effects of lorazepam: A dose related study

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dc.contributor.author Ikram, Huma
dc.contributor.author Atique, Iqra
dc.contributor.author Perveen, Shahla
dc.contributor.author Zakir, Rumaisa
dc.contributor.author Haleem, Darakhshan J
dc.date.accessioned 2022-10-20T09:54:55Z
dc.date.available 2022-10-20T09:54:55Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13423
dc.description.abstract Present study was designed to monitor the dose dependent effects of lorazepam; a benzodiazepine (CNS depressant). It is the primary drug of choice for treatment of anxiety and to produce calming effects. However, repeated administration of this lorazepam causes dependence and this might be caused by increased dopaminergic neurotransmission. Besides dopamine, 5-hydroxy tryptamine (5-HT) has also been reported to have pivotal role in the pathophysiology as well as treatment of anxiety and addiction. Repeated administration of lorazepam might involve altered 5-HT metabolism as well. Present study was therefore designed to monitor dose-dependent effects of lorazepam and to select its optimum dose for further experiments and pharmacological interventions. Effects of lorazepam were monitored on food intake, growth rate, activities in familiar and novel environments, light dark box activity, forced swim test and metabolism of dopamine and 5-HT. oral administration of lorazepam was done at the doses of 0mg/kg, 2mg/kg, 4mg/kg and 6mg/kg. Behaviors parameters were monitored following single administration of lorazepam. Rats were decapitated and whole brain samples were collected and stored at -70°C until neurochemical analysis by HPLC-EC. Findings from the present study could be implicated to increased therapeutic utility of lorazepam and related benzodiazepines. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Lorazepam en_US
dc.subject Ativan en_US
dc.subject light dark box activity en_US
dc.subject anxiety en_US
dc.subject forced swim test en_US
dc.title Neurochemical and behavioral effects of lorazepam: A dose related study en_US
dc.type Article en_US


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