Abstract:
Gentamicin (GM) is a generally utilized as an antibiotic against dangerous and life threatening
contaminations, yet its value is restricted by the development of nephrotoxicity. The present investigation was intended
to decide the defensive impact of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rabbits. Quantitative
assessment of gentamicin-induced structural changes and level of functional modifications in the kidneys were
performed by biochemical examinations keeping in mind the end goal is to decide the potential protective impacts of SA
co-administration with gentamicin. Gentamicin was seen to cause a serious nephrotoxicity which was proved by a
plasma urea, plasmacreatinine, plasma uric acid, plasma Na+
, plasma K+
, intra-erythrocyte Na+
and intra-erythrocyte K+
levels. On the other hand, simultaneous SA administration protected kidney tissue against the oxidative damage and the
nephrotoxic effect caused by GM treatment. The outcomes from our investigation show that SA supplement lessens
oxidative-stress related to renal damage by reducing oxygen free radicals in gentamicin-treated rabbits.
