Abstract:
Salmonella.typhi a typhoid causing organism, has developed resistance to oral first line
(Ampicillin and Flouroquinolones) and oral third line antibiotics (Chloramphenicol) due to
enzymatic and genetic changes. As a result XDR Fever as an epidemic has taken the world
by storm with its vivid target of engulfing the mortals and resist towards countless medical
therapies. Here, a set of medical regime with precautions are being posed to let the steam out
and control the disease. Diverse variety of journal with articles over the subject disease has
been scrutinized to get a clear picture of the epidemic from year 2007 till 2020. Following
credible databases have been probed: Pub med, ASM Journal, NEJM organization, Oxford
Academy, Cidrap, ReAct, Sciencemeg, New England Journal of Medicine. On the basis of
literature evaluation, up till now 17756 cases have been observed in Southern part of
Pakistan regarding XDR typhoid among which 2000 cases are reported to be fatal. The
frequently prescribed treatment against XDR are Azithromycin and/or Carbapanem, while
many other drugs with increased immunity and better treatment are available which are
unaffordable for Pakistan. To avoid antibiotic resistance, Pakistan should start Antimicrobial resistance program (AMR program) as well as Anti-microbial stewardship
program (ASP).
