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Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients

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dc.contributor.author Xu, Wei
dc.contributor.author Qian, Lei
dc.contributor.author Yuan, Xiaoyan
dc.contributor.author Lu, Yong
dc.date.accessioned 2022-10-20T10:04:46Z
dc.date.available 2022-10-20T10:04:46Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13459
dc.description.abstract To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF). 126 CHF patients were divided into control group (n=13, sodium nitroprusside) and combined treatment group (n=63, sodium nitroprusside + hydralazine). Serum Adropin and BNP levels and left ventricular mass index (LVMI) of patients before treatment and 10 days after treatment were recorded, so did patient’s end-point events. It was found that compared with those before treatment, the serum levels of Adropin, BNP, and LVMI in combined group and control group after 10 days of treatment were lower (P<0.05). The end-point event rate in the combined group was 19.05% (12/63). The serum levels of Adropin, BNP, and LVMI in the combined group with end-point events were higher than those of patients without end-point events (P<0.05). Spearman correlation analysis showed that serum levels of Adropin and BNP were positively correlated with LVMI and the end-point events rate (P<0.05). To sum up, hydralazine combined with sodium nitroprusside treatment can effectively reduce serum Adropin and BNP levels, and the risk of left ventricular remodeling and poor prognosis in patients with CHF en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Hydralazine en_US
dc.subject nitrate en_US
dc.subject chronic heart failure en_US
dc.subject adropin en_US
dc.subject brain natriuretic peptide en_US
dc.subject left ventricular remodeling en_US
dc.title Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients en_US
dc.type Article en_US


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