Abstract:
To investigate the effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients
with severe pneumonia and respiratory failure requiring mechanical ventilation. 70 patients with severe pneumonia
complicated with respiratory failure who were treated with mechanical ventilation were selected and divided into the
combined group and the control group. The control group underwent mechanical ventilation treatment and used
dexmedetomidine for sedation and analgesia, while the combined group had sufentanil analgesia in addition to the
treatment of the control group. Ramsay sedation score, visual analogue scale (VAS) and pulmonary function indicators
were compared between the two groups before treatment, 24h after treatment, and after extubation. After 24h treatment
and extubation, the blood oxygen saturation (SpO2), oxygenation index (OI) and arterial oxygen partial pressure (PaO2)
in the combined group were higher than those in the control group; at the same time, the serum interleukin 6 (IL-6),
tumor necrosis factor α (TNF-α), and malondialdehyde (MDA) levels were lower (P<0.05). Mortality during
hospitalization of the combined group was lower than the control group (P<0.05). Dexmedetomidine combined with
sufentanil citrate can effectively improve sedative and analgesic effects, stress response, pulmonary function and
prognosis in patients with severe respiratory failure requiring mechanical ventilation.
