Abstract:
SARS-Covid-19 infection got spread in many countries and WHO declared it as a serious global Pandemic.
Pro-inflammatory cytokines storm generated by Covid-19 infection hyper-activates inflammatory response in host body,
resulting in elevated release of inflammatory biomarkers. Present article describes the characteristic profile of these
inflammatory and related biomarkers in a total of 48 critically ill Covid-19 patients, (Male = 38, F = 10), with mildly ill
to severe, critically ill status and thus grouped accordingly. Inflammatory Biomarkers, Ferritin, ProCalcitonin, CReactive Protein, coagulation marker-D-Dimer, chemical analytes, Protein, Albumin, BUN, Bilirubin, Creatinine, and
enzymes, Lactate Dehydrogenase, γ-Glutamyl transpeptidases, Alkaline phosphatase were routine analyzed by standard
methods described earlier. D-dimer, Ferritin, CRP and Procalcitonin exhibited variable alterations (P<0.05 to P<0.001),
more markedly in critically ill patients than in the mild and severe. Biochemical analytes and enzymatic parameters
showed elevated levels (P<0.05 to P<0.01) mostly in critically ill category of patients when compared with mild or
severe, except total protein and albumin, which remained non-significant. It is concluded that cytokine, chemokines and
pro-inflammatory markers, which released in abnormally high concentrations in Covid-19 patients of variable syndrome
intensity, are significant indicators of disease severity, progression and success of treatments. As the pharmacological
options may vary with the different stages of the disease therefore identifying the correct stage of the disease may be
very useful in selecting the best option.
