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Synthesis, spectral analysis and biological evaluation of 2- {[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives

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dc.contributor.author Aziz-ur-Rehman
dc.contributor.author Gul Khan, Samreen
dc.contributor.author Naqvi, Syed Ali Raza
dc.contributor.author Ahmad, Matloob
dc.contributor.author Akhtar, Naheed
dc.contributor.author Bokhari, Tanveer Hussain
dc.contributor.author Irfan, Muhammad
dc.contributor.author Usman, Ali
dc.contributor.author Batool, Sidra
dc.contributor.author Rasool, Shahid
dc.contributor.author Shah, Syed Adnan Ali
dc.contributor.author Shahid, Muhammad
dc.date.accessioned 2022-10-20T10:11:12Z
dc.date.available 2022-10-20T10:11:12Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13490
dc.description.abstract A series of new derivatives of 4-(2-chloroethyl)morpholine hydrochloride (5) were efficiently synthesized. Briefly, different aromatic organic acids (1a-f) were refluxed to acquire respective esters (2a-f) using conc. H2SO4 as catalyst. The esters were subjected to nucleophillic substitution by monohydrated hydrazine to acquire hydrazides (3a-f). The hydrazides were cyclized with CS2 in the presence of KOH to yield corresponding oxadiazoles (4a-f). Finally, the derivatives, 6a-f, were prepared by reacting oxadiazoles (4a-f) with 5 using NaH as activator. Structures of all the derivatives were elucidated through 1D-NMR EI-MS and IR spectral data. All these molecules were subjected to antibacterial and hemolytic activities and showed good antibacterial and hemolytic potential relative to the reference standards. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Hemolytic activity en_US
dc.subject antibacterial activity en_US
dc.subject morpholine en_US
dc.subject 1,3,4-oxadiazole en_US
dc.title Synthesis, spectral analysis and biological evaluation of 2- {[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives en_US
dc.type Article en_US


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