dc.contributor.author |
Aziz-ur-Rehman |
|
dc.contributor.author |
Gul Khan, Samreen |
|
dc.contributor.author |
Naqvi, Syed Ali Raza |
|
dc.contributor.author |
Ahmad, Matloob |
|
dc.contributor.author |
Akhtar, Naheed |
|
dc.contributor.author |
Bokhari, Tanveer Hussain |
|
dc.contributor.author |
Irfan, Muhammad |
|
dc.contributor.author |
Usman, Ali |
|
dc.contributor.author |
Batool, Sidra |
|
dc.contributor.author |
Rasool, Shahid |
|
dc.contributor.author |
Shah, Syed Adnan Ali |
|
dc.contributor.author |
Shahid, Muhammad |
|
dc.date.accessioned |
2022-10-20T10:11:12Z |
|
dc.date.available |
2022-10-20T10:11:12Z |
|
dc.date.issued |
2021-01-16 |
|
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/13490 |
|
dc.description.abstract |
A series of new derivatives of 4-(2-chloroethyl)morpholine hydrochloride (5) were efficiently synthesized.
Briefly, different aromatic organic acids (1a-f) were refluxed to acquire respective esters (2a-f) using conc. H2SO4 as
catalyst. The esters were subjected to nucleophillic substitution by monohydrated hydrazine to acquire hydrazides (3a-f).
The hydrazides were cyclized with CS2 in the presence of KOH to yield corresponding oxadiazoles (4a-f). Finally, the
derivatives, 6a-f, were prepared by reacting oxadiazoles (4a-f) with 5 using NaH as activator. Structures of all the
derivatives were elucidated through 1D-NMR EI-MS and IR spectral data. All these molecules were subjected to
antibacterial and hemolytic activities and showed good antibacterial and hemolytic potential relative to the reference
standards. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi |
en_US |
dc.subject |
Hemolytic activity |
en_US |
dc.subject |
antibacterial activity |
en_US |
dc.subject |
morpholine |
en_US |
dc.subject |
1,3,4-oxadiazole |
en_US |
dc.title |
Synthesis, spectral analysis and biological evaluation of 2- {[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives |
en_US |
dc.type |
Article |
en_US |