Abstract:
The aim of this study was to design and develop controlled porosity osmotic pumps containing glibenclamide
(as an insoluble agent) coated with nano-scale pore formers. Solubility enhancement methods including co-grinding with
an anionic surfactant and pH adjustment in core formulation were employed and the prepared cores were coated with
nano-suspension coating method. The prepared nano-porous osmotic pump (CPOP) system assessed by comparative
parameters including D24h (cumulative release percentage after 24h), tL (lag time of the drug release from device), drug
release rate from device and RSQzero. Solubility studies of glibenclamide co-ground with an anionic surfactant showed
that by increasing the concentration of SLS to 83.33% (ratio of drug: SLS 1:5) in the presence of calcium carbonate, the
solubility of glibenclamide was enhanced remarkably. Release study also displayed enhanced D24h and improved kinetic
related parameter (RSQ zero) by increasing SLS and calcium carbonate in the core formulation via nano-porous CPOPs. It
can be concluded that by employing both co-grinding technology and pH adjustment method in core formulation of
glibenclamidenano-suspension coated CPOPs, enhanced D24h, drug release rate and improved kinetic related parameter
(RSQ zero) was achieved.
