PASTIC Dspace Repository

Design and formulation of nano-porous controlled porosity osmotic pumps (CPOPs) containing a poorly water soluble drug, glibenclamide

Show simple item record

dc.contributor.author Azharshekoufeh B, Leila
dc.contributor.author Javadzadeh, Yousef
dc.contributor.author Barzegar Jalali, Mohammad
dc.contributor.author Nokhodchi, Ali
dc.contributor.author Shokri, Javad
dc.date.accessioned 2022-10-21T10:39:40Z
dc.date.available 2022-10-21T10:39:40Z
dc.date.issued 2019-09-15
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13554
dc.description.abstract The aim of this study was to design and develop controlled porosity osmotic pumps containing glibenclamide (as an insoluble agent) coated with nano-scale pore formers. Solubility enhancement methods including co-grinding with an anionic surfactant and pH adjustment in core formulation were employed and the prepared cores were coated with nano-suspension coating method. The prepared nano-porous osmotic pump (CPOP) system assessed by comparative parameters including D24h (cumulative release percentage after 24h), tL (lag time of the drug release from device), drug release rate from device and RSQzero. Solubility studies of glibenclamide co-ground with an anionic surfactant showed that by increasing the concentration of SLS to 83.33% (ratio of drug: SLS 1:5) in the presence of calcium carbonate, the solubility of glibenclamide was enhanced remarkably. Release study also displayed enhanced D24h and improved kinetic related parameter (RSQ zero) by increasing SLS and calcium carbonate in the core formulation via nano-porous CPOPs. It can be concluded that by employing both co-grinding technology and pH adjustment method in core formulation of glibenclamidenano-suspension coated CPOPs, enhanced D24h, drug release rate and improved kinetic related parameter (RSQ zero) was achieved. en_US
dc.language.iso en_US en_US
dc.subject Solid dispersion en_US
dc.subject co-grinding en_US
dc.subject nano-suspension coating en_US
dc.subject CPOP en_US
dc.subject glibenclamide en_US
dc.title Design and formulation of nano-porous controlled porosity osmotic pumps (CPOPs) containing a poorly water soluble drug, glibenclamide en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account