Abstract:
The objective was to develop eperisone HCl sustained-release pellets through extrusion spheronization
technique and to determine the influence of different hydrophobic (polymeric based and wax-based) and hydrophilic
(polymeric based) matrix former on the release of eperisone HCl (BCS class I drug) and on pellet sphericity. The pellet
formulations consisted of different hydrophobic and hydrophilic matrix formers like HPMC K4M (10-20%) HPMC
K15M (10%), EC (7cps) (10-20%), Carnauba wax (10-20%), Compritol ATO 888 (10-20%), Glyceryl monostearate
(10%), lactose and microcrystalline cellulose. The initial burst release of the drug from matrix pellet formulations was
effectively controlled by coating with 5% EC (ethylcellulose) dispersion. The dissolution profile and drug release
kinetics of coated pellet formulations were determined at both acidic and basic pH medium. SEM (Scanning electron
microscope) technique was used to determine the surface morphology and cross-section of F5 and F7 pellet formulation.
The mechanism of drug release of coated formulation followed non-Fickian diffusion. FTIR spectroscopy was conducted
and no drug and excipients interaction was observed. The results had shown that optimized coated formulation was F5
and F7 which effectively extend the drug release for 12 hours.
