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Formulation and optimization of dimenhydrinate emulgels for topical delivery using response surface methodology

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dc.contributor.author Khan, Qalander
dc.contributor.author Shah, Syed Nisar Hussain
dc.contributor.author Arshad, Muhammad Sohail
dc.contributor.author Usman, Faisal
dc.contributor.author Khalil, Ruqaiya
dc.contributor.author Zaheer Ul-Haq
dc.contributor.author Siddiqui, Faheem Ahmed
dc.contributor.author Hussain, Talib
dc.contributor.author Yousaf, Abid Mehmood
dc.contributor.author AA Rizvi, Syed
dc.contributor.author Shahzad, Yasser
dc.date.accessioned 2022-10-24T08:39:26Z
dc.date.available 2022-10-24T08:39:26Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13575
dc.description.abstract Development of dimenhydrinate (DMN) emulgel formulation has been described in this work with enhanced permeation for transdermal delivery of DMN for effective management of motion sickness. Various DMN emulgel formulations were prepared using central composite design in response surface methodology. Propylene glycol and olive oil were used in varying ratios as permeation enhancers along-with carbopol-934 as gelling agent. Prepared formulations were evaluated by physico-chemical properties, stability and Fourier transform infrared spectroscopy (FTIR) studies. Invitro drug release was studied using cellophane membrane. Formulation F2 showed maximum drug permeation following diffusion-based release mechanism and was used in further studies. Rat skin was used in Franz cell for ex-vivo studies to determine various permeation kinetic parameters. FTIR studies provided no evidence of chemical interaction between DMN and polymers used, whereas molecular docking revealed formation of a stable complex in the presence of aqueous environment with stable intermolecular binding and the complex was well hydrated. No evidence of skin irritation was observed in human volunteers following application of the optimized formulation. Histopathology data of the rat skin showed a decreased proliferation of the lymphocytes whereas monocytes were induced. In conclusion, combination of propylene glycol and olive oil was successfully employed for delivery of DMN through transdermal route with good permeability and prolonged release time that can be highly beneficial in treating motion sickness in unusual circumstances. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Dimenhydrinate en_US
dc.subject emulgel en_US
dc.subject motion sickness en_US
dc.subject molecular docking en_US
dc.subject response surface methodology en_US
dc.subject permeation en_US
dc.title Formulation and optimization of dimenhydrinate emulgels for topical delivery using response surface methodology en_US
dc.type Article en_US


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