dc.contributor.author |
Abid, Farah |
|
dc.contributor.author |
Saleem, Muhammad |
|
dc.contributor.author |
Zaidi, Awais Ali |
|
dc.contributor.author |
Mobashar, Aisha |
|
dc.contributor.author |
Yasir, Saliha |
|
dc.date.accessioned |
2022-10-24T08:40:29Z |
|
dc.date.available |
2022-10-24T08:40:29Z |
|
dc.date.issued |
2021-01-16 |
|
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/13577 |
|
dc.description.abstract |
Natural Plants are broadly used in treating inflammatory disorders. The current study focused on evaluating
the hepato-protective and anti-inflammatory potential of A. modesta in MnCL2 induced hepatotoxicity and liver
inflammation. The MnCl2 induce 6.0mg/kg was given for 30 days (p.o) to induced hepatotoxicity and liver
inflammation. The ethanolic extract of A. modesta were given orally at the dose of 100mg/kg/day. The in vivo
inflammatory manganese induced hepatotoxic model is used for evaluating the acacia heap to-protective effect. Gas
chromatography-mass spectrometry analyses were performed to find out compounds responsible for anti-inflammatory
properties. Results showed that administration of ethanolic extract (100 mg/kg), altogether diminished inflammation of
the liver, expanded liver capacity, oxidative stress and his to-pathological outcomes in the current study compared with
disease rats. The beneficial outcomes of A. modesta extract were observed on liver inflammation. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi |
en_US |
dc.subject |
Inflammation |
en_US |
dc.subject |
Celecoxib |
en_US |
dc.subject |
Acacia modesta |
en_US |
dc.subject |
β-Sitosterol |
en_US |
dc.subject |
in silico docking |
en_US |
dc.title |
Acacia modesta attenuates MnCl2 induced hepatotoxicity, oxidative stress and hepatic inflammation in wistar rats |
en_US |
dc.type |
Article |
en_US |