Abstract:
This study centered on the ability of the cross-linked nano-sponge system to load the drug and to improve its
physicochemical and dissolution properties. A spectrophotometric method was used to determine the wavelength of
maximum absorbance of the drug. The ultrasonic-assisted synthesis method was used for nano-sponge preparation.
Solution-state interactions, encapsulation efficiency and production yield, and in-vitro release were also investigated.
Nano-sponges were characterized by Transmission Electron-Microscopy (TEM), Scanning Electron-Microscopy (SEM),
Fourier Transform-Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and X-Ray Diffractometry
(X-RD) studies. The maximum absorption wavelength of N-acetyl–L-carnosine was found to be at 210 nm. Solutionstate interaction studies revealed a bathochromic shift. The production yield of nano-sponges ranged from 59.58% to
72.54%. In-vitro release study showed a sustained drug release for 228 hours. TEM images showed regular spherical
shapes and sizes of nano-sponges. Their average particle size ranged from 28 nm to 79.2 nm. DSC data documented the
drug-polymer interactions. FT-IR determined the presence of functional groups. X-RD showed the physicochemical
characteristics of nano-sponges. Proving successful development of N-acetyl–L-carnosine polymeric nano-sponge
system with a suitable drug delivery over an extended period beside a noticeable improvement in the physicochemical
characterization.
