dc.contributor.author |
Badawi, Alia |
|
dc.contributor.author |
Mohammed, Magdy |
|
dc.contributor.author |
Khalil, Rawia |
|
dc.contributor.author |
Ali, Ruddy |
|
dc.contributor.author |
Taleb, Sally Abou |
|
dc.date.accessioned |
2022-10-24T08:41:27Z |
|
dc.date.available |
2022-10-24T08:41:27Z |
|
dc.date.issued |
2021-01-16 |
|
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/13579 |
|
dc.description.abstract |
This study centered on the ability of the cross-linked nano-sponge system to load the drug and to improve its
physicochemical and dissolution properties. A spectrophotometric method was used to determine the wavelength of
maximum absorbance of the drug. The ultrasonic-assisted synthesis method was used for nano-sponge preparation.
Solution-state interactions, encapsulation efficiency and production yield, and in-vitro release were also investigated.
Nano-sponges were characterized by Transmission Electron-Microscopy (TEM), Scanning Electron-Microscopy (SEM),
Fourier Transform-Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and X-Ray Diffractometry
(X-RD) studies. The maximum absorption wavelength of N-acetyl–L-carnosine was found to be at 210 nm. Solutionstate interaction studies revealed a bathochromic shift. The production yield of nano-sponges ranged from 59.58% to
72.54%. In-vitro release study showed a sustained drug release for 228 hours. TEM images showed regular spherical
shapes and sizes of nano-sponges. Their average particle size ranged from 28 nm to 79.2 nm. DSC data documented the
drug-polymer interactions. FT-IR determined the presence of functional groups. X-RD showed the physicochemical
characteristics of nano-sponges. Proving successful development of N-acetyl–L-carnosine polymeric nano-sponge
system with a suitable drug delivery over an extended period beside a noticeable improvement in the physicochemical
characterization. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi |
en_US |
dc.subject |
Nano-sponge |
en_US |
dc.subject |
hydroxy-propyl-β-cyclodextrin |
en_US |
dc.subject |
N-acetyl–L-carnosine |
en_US |
dc.subject |
ultrasonic technique release |
en_US |
dc.title |
Effectuation of loading a natural acetyl carnosine derivative within a promising cross-linked cyclodextrin spongey-like nanospheres on Physicochemical characterization and release behavior |
en_US |
dc.type |
Article |
en_US |