Abstract:
The objective of the current research was to validate the hepatoprotective and anti-hyperlipidemic activities of
C. bonduc seed kernels (CBSK) and G. sylvestre leaves (GSL) hydro-methanolic extracts, separately and in combination
(CBSKE+GSLE) in alloxan-induced diabetic rat model for 28 days. Diabetes was induced by i.p. injection of alloxan
monohydrate (140 mg/kg body weight) to albino Wistar rats. Six groups of rats (n=9) were used. Group 1 was the
normal control; group 2 was diabetic control. After induction of diabetes metformin (150mg/kg), CBSKE (400mg/kg),
GSLE (400 mg/kg) and CBSKE+GSLE (400mg/kg) were administered to diabetic rat groups 3, 4, 5 and 6 respectively
for a period of 28 days. Diabetic rats exhibited an increase in serum blood glucose, liver function markers and
lipid profile. Treatment of diabetic rats with metformin, CBSKE, GSLE and CBSKE+GSLE for 4 weeks
significantly produced hepatoprotective and hypolipidemic effect via amelioration of raised serum glucose, liver
profile, and lipid profile. The outcomes of this study suggest that G. sylvestre leaves and C. bonduc seed kernels have
hepatoprotective and hypolipidemic potential which possibly help in managing diabetes-induced liver injury and
hyperlipidemia.
