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Hepatoprotective and hypolipidemic activities of Caesalpinia bonduc seed kernels and Gymnema sylvestre leaves extracts in alloxan-induced diabetic rats

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dc.contributor.author Kousar, Shaneel
dc.contributor.author Aslam, Bilal
dc.contributor.author Muhammad, Faqir
dc.contributor.author Khan, Junaid Ali
dc.date.accessioned 2022-10-24T08:43:20Z
dc.date.available 2022-10-24T08:43:20Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13582
dc.description.abstract The objective of the current research was to validate the hepatoprotective and anti-hyperlipidemic activities of C. bonduc seed kernels (CBSK) and G. sylvestre leaves (GSL) hydro-methanolic extracts, separately and in combination (CBSKE+GSLE) in alloxan-induced diabetic rat model for 28 days. Diabetes was induced by i.p. injection of alloxan monohydrate (140 mg/kg body weight) to albino Wistar rats. Six groups of rats (n=9) were used. Group 1 was the normal control; group 2 was diabetic control. After induction of diabetes metformin (150mg/kg), CBSKE (400mg/kg), GSLE (400 mg/kg) and CBSKE+GSLE (400mg/kg) were administered to diabetic rat groups 3, 4, 5 and 6 respectively for a period of 28 days. Diabetic rats exhibited an increase in serum blood glucose, liver function markers and lipid profile. Treatment of diabetic rats with metformin, CBSKE, GSLE and CBSKE+GSLE for 4 weeks significantly produced hepatoprotective and hypolipidemic effect via amelioration of raised serum glucose, liver profile, and lipid profile. The outcomes of this study suggest that G. sylvestre leaves and C. bonduc seed kernels have hepatoprotective and hypolipidemic potential which possibly help in managing diabetes-induced liver injury and hyperlipidemia. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Caesalpinia bonduc en_US
dc.subject diabetes en_US
dc.subject Gymnema sylvestre en_US
dc.subject hepatotoxicity en_US
dc.subject hyperlipidemia en_US
dc.title Hepatoprotective and hypolipidemic activities of Caesalpinia bonduc seed kernels and Gymnema sylvestre leaves extracts in alloxan-induced diabetic rats en_US
dc.type Article en_US


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