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Oral bioavailability studies of niosomal formulations of Cyclosporine A in albino rabbits

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dc.contributor.author Mujeeb Ur Rehman
dc.contributor.author Rasul, Akhtar
dc.contributor.author Khan, Muhammad Imran
dc.contributor.author Rasool, Maria
dc.contributor.author Abbas, Ghulam
dc.contributor.author Masood, Feroza
dc.contributor.author Nazir, Imran
dc.contributor.author Iqbal, Muhammad
dc.contributor.author Islam, Nayyer
dc.contributor.author Hameed, Misbah
dc.contributor.author Shah, Pervaiz Akhtar
dc.date.accessioned 2022-10-24T08:45:10Z
dc.date.available 2022-10-24T08:45:10Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13583
dc.description.abstract Cyclosporine A (CsA) is an immunosuppressant agent. Two niosomal formulations of CsA, FTS and FSB were formulated. Both formulations were studied in terms of size, polydispersity index (PDI), morphology and entrapment efficacy etc. Niosomal formulations FTS and FSB and plain aqueous dispersion were given to three assemblies of Albino rabbits (n=8 per group). CsA levels in plasma were determined at appropriate time intervals and pharmacokinetic parameters were evaluated. The percentage entrapment efficiencies of FTS and FSB were found to be 77.29 and 89.31% for respectively. Transmission electron microscopy results indicated spherical nature of niosomes. In vivo studies demonstrated that the value of Cmax for the FSB formulation was 1968.419 ng/ml and it was 1498.951 ng/ml and 1073.87 ng/ml for FTS and aqueous dispersion of CsA (control) respectively. It was found that both niosomal formulation FTS & FSB presented significantly high (p<0.05) Cmax, AUC0-t, MRT 0-inf and half-life (t1/2) as associated to plain drug dispersion. However niosomal formulation FSB exhibited better in-vivo performance as compared to FTS. It was established that CsA can be successfully entrapped in niosomes. So niosomes are promising vehicle for CsA oral delivery. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject In vivo study en_US
dc.subject niosomes en_US
dc.subject bioavailability en_US
dc.subject cyclosporine A en_US
dc.subject formulation en_US
dc.title Oral bioavailability studies of niosomal formulations of Cyclosporine A in albino rabbits en_US
dc.type Article en_US


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