Abstract:
SARS-CoV-2, a new world coronavirus belonging to class Nidovirales of Coronaviridae family causes
COVID-19 infection which is the leading cause of death worldwide. Currently there are no approved drugs and vaccines
available for the prevention of COVID-19 infection, although couples of immunizations are being tested in clinical trials.
However, the present efforts are focused on computational vaccination technique for evaluating candidates to design
multi-epitope-based vaccine against pathogenic mechanism of novel SARS-COV-2. Based on recent published evidence,
we recognized spike glycoprotein and envelope small membrane protein are the potential targets to combat the
pathogenic mechanism of SARS-CoV-2. Similarly, in the present study we identified epitope of both B and T cell
associated with these proteins. Extremely antigenic, conserve, immunogenic and nontoxic epitope of B and T cell of
Spike protein are WPWYVWLGFI, SRVKNLNSSEGVPDLLV whereas the CWCARPTCIK and YCCNIVNVSL are
associated with envelope small membrane protein were selected as potential candidate for vaccine designing. These
epitopes show virtuous interaction with HLAA0201 during molecular docking analysis. Under simulation protocol the
predicted vaccine candidates show stability. Collectively, this work provides novel potential candidates for epitope-based
vaccine designing against COVID-19 infection.
