Abstract:
Piperazine moiety is found as an efficient pharmacological scaffold in various drugs. To explore the
anticancer potential of piperazine framework, a series of novel N-acetamides derivatives of phenyl piperazine containing
di-thio-carbamate moiety was designed and synthesized. 1HNMR, 13CNMR, FT-IR and mass spectrometry were used for
the structures elucidation of these derivatives. In-vitro cytotoxic evaluation of the prepared novel compounds against
lung carcinoma A-549 was carried out using standard MTT assay. All the di-thio-carbamate-piperazine derivatives
exhibited moderate to excellent cytotoxic potential against A-549 cell line based on cell viability. Particularly, 6e was
found to be the most potent derivative with cell viability 34.12±0.73 % at 100 µg/mL concentration and represents
promising lead compound for future progress.