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Synthesis and anticancer evaluation of 2-oxo-2-(arylamino) ethyl 4- phenylpiperazine-1-carbodithioates

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dc.contributor.author Hafeez, Freeha
dc.contributor.author Zahoor, Ameer Fawad
dc.contributor.author Rasul, Azhar
dc.contributor.author Ahmad, Sajjad
dc.contributor.author Mansha, Asim
dc.date.accessioned 2022-10-24T08:47:50Z
dc.date.available 2022-10-24T08:47:50Z
dc.date.issued 2021-01-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13587
dc.description.abstract Piperazine moiety is found as an efficient pharmacological scaffold in various drugs. To explore the anticancer potential of piperazine framework, a series of novel N-acetamides derivatives of phenyl piperazine containing di-thio-carbamate moiety was designed and synthesized. 1HNMR, 13CNMR, FT-IR and mass spectrometry were used for the structures elucidation of these derivatives. In-vitro cytotoxic evaluation of the prepared novel compounds against lung carcinoma A-549 was carried out using standard MTT assay. All the di-thio-carbamate-piperazine derivatives exhibited moderate to excellent cytotoxic potential against A-549 cell line based on cell viability. Particularly, 6e was found to be the most potent derivative with cell viability 34.12±0.73 % at 100 µg/mL concentration and represents promising lead compound for future progress. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject N-Phenyl piperazine en_US
dc.subject cytotoxicity en_US
dc.subject di-thio-carbamates en_US
dc.subject human lung cancer en_US
dc.subject anti-cancer en_US
dc.title Synthesis and anticancer evaluation of 2-oxo-2-(arylamino) ethyl 4- phenylpiperazine-1-carbodithioates en_US
dc.type Article en_US


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