dc.contributor.author |
Hafeez, Freeha |
|
dc.contributor.author |
Zahoor, Ameer Fawad |
|
dc.contributor.author |
Rasul, Azhar |
|
dc.contributor.author |
Ahmad, Sajjad |
|
dc.contributor.author |
Mansha, Asim |
|
dc.date.accessioned |
2022-10-24T08:47:50Z |
|
dc.date.available |
2022-10-24T08:47:50Z |
|
dc.date.issued |
2021-01-16 |
|
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/13587 |
|
dc.description.abstract |
Piperazine moiety is found as an efficient pharmacological scaffold in various drugs. To explore the
anticancer potential of piperazine framework, a series of novel N-acetamides derivatives of phenyl piperazine containing
di-thio-carbamate moiety was designed and synthesized. 1HNMR, 13CNMR, FT-IR and mass spectrometry were used for
the structures elucidation of these derivatives. In-vitro cytotoxic evaluation of the prepared novel compounds against
lung carcinoma A-549 was carried out using standard MTT assay. All the di-thio-carbamate-piperazine derivatives
exhibited moderate to excellent cytotoxic potential against A-549 cell line based on cell viability. Particularly, 6e was
found to be the most potent derivative with cell viability 34.12±0.73 % at 100 µg/mL concentration and represents
promising lead compound for future progress. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi |
en_US |
dc.subject |
N-Phenyl piperazine |
en_US |
dc.subject |
cytotoxicity |
en_US |
dc.subject |
di-thio-carbamates |
en_US |
dc.subject |
human lung cancer |
en_US |
dc.subject |
anti-cancer |
en_US |
dc.title |
Synthesis and anticancer evaluation of 2-oxo-2-(arylamino) ethyl 4- phenylpiperazine-1-carbodithioates |
en_US |
dc.type |
Article |
en_US |