Abstract:
The aim of the present study was to evaluate the cardioprotective activity of boswellic acids in doxorubicin
(DOX) induced cardiotoxicity. DOX (2.5mg/kg) was used intraperitoneally in rats to induce cardiotoxicity in six divided
doses every alternate day over a period of two weeks. Dexrazoxane (10:1) was used as a standard drug. Boswellic acids
(250, 500 and 750 mg/kg) were orally administered to rats for 14 days. After 14 days, rats were sacrificed, and blood was
withdrawn through cardiac puncture. The blood lipid profile and cardiac biomarkers including LDH, CK-MB, CPK,
SGOT and troponin T were measured. The heart of rats was isolated for histopathological studies. Graphpad Prism was
used for statistical analysis. There was a significant increase in the level of cardiac enzymes and complete lipid profile
parameters in diseased group as compared to control group. Pre-treatment with boswellic acids decreased level of all the
measured parameters and decreased the severity of myocardial damage as supported by histopathological studies. It was
concluded that boswellic acids possess cardioprotective potential by lowering cardiac biomarkers and blood lipid profile.
Thus, boswellic acids might act as cardioprotective agent against doxorubicin induced cardiotoxicity.
