Comparison of efficacy of Metformin versus Pioglitazone on Ovulation in patients of polycystic ovarian syndrome

Abstract

Aim: To compare the efficacy of Metformin with Pioglitazone for ovulation induction in patients presenting with polycystic ovarian syndrome. Study Design: The study was randomized control trial. Setting: Department of Obstetrics and Gynaecology, Lady Willingdon Hospital Lahore Duration: from 28-11-2016 to 27-05-2017 (6 months). Methods: The patients number 102 were enrolled in the study after fulfilling he inclusion criteria. Informed consent and demographic information was taken. The patients were divided into two groups. Efficacy was observed after 06 months of administration of therapies. Data collected was entered and analyzed on SPSS version 20. Result: In womanwith mean age of Pioglitazone group was 28.18+4.55 years and in metformin group was 28.16±4.78 years. The ovulation was noted in 43 patients with Pioglitazone and 30 patients with metformin. Conception occurred in 32 patients with Pioglitazone and 9 patients with metformin. Significant difference has been observed in both groups regarding (p<0.05). Conclusion: It has been proved in our study that effectiveness of Pioglitazone is statistically more significant than metformin in ovulation induction.