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Terpenoid-lupeol of red dragon fruit (Hylocereus polyrhizus) and its immunomodulatory activity

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dc.contributor.author Wahdaningsih, Sri
dc.contributor.author Wahyuono, Subagus
dc.contributor.author Riyanto, Sugeng
dc.contributor.author Murwanti, Retno
dc.date.accessioned 2022-10-26T09:59:50Z
dc.date.available 2022-10-26T09:59:50Z
dc.date.issued 2020-03-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13732
dc.description.abstract Red dragon fruit (Hylocereus polyrhizus, (F.A.C. Weber) Britton and Rose) has been reported to have various biological activities such as antimicrobial, anti-hypercholesterolemia, anti-diabetes mellitus, cardiovascular risk reduction, health supplement, and melanoma cell inhibitory. The red thick peel of this fruit is just practically a waste that is possibly utilized to maintain health, therefore this research aimed to isolate and identify active compounds of H. Polyrhizus peels which can improve the immune system of body. In order to simplify methanol extract was partition and fractionation. The active compounds of petroleum ether fraction were separated and purified using preparative thin layer chromatography. The identification of the compounds structure was conducted through spectroscopic techniques, including UV, FT-IR, 13CNMR and 1HNMR spectroscopy. The data of spectra revealed that the isolate is lupeol. The statistical analysis of macrophage activity showed that the isolate with concentrations of 100, 50, 25, 12.5 and 6.25µg/mL could activate the macrophages higher than control negative. Terpenoid generated from the isolation of Hylocereus polyrhizus was identified as lupeol (1-isopropenyl-3a,5a,5b,8,8,11a-hexamethyl-eicosahydrocyclopenya [α] chrysen-9ol. In vitro test shows that the isolated compound had an immunomodulatory activity by increases macrophage phagocytosis of latex beads en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject H. polyrhizus en_US
dc.subject petroleum ether fraction en_US
dc.subject terpenoids - lupeol en_US
dc.subject immunomodulator en_US
dc.title Terpenoid-lupeol of red dragon fruit (Hylocereus polyrhizus) and its immunomodulatory activity en_US
dc.type Article en_US


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